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The only time you need to worry about signal reflections in any electronic system is when the impedance discontinuity is longer than 1/6 the distance that the rise time of the signal occupies in the wire.   For a sine wave, that rising edge represents 1/4λ, so (1/4λ)/6= 1/24 λ.   Simply put, any connection to a mismatched transmission line that is longer than 1/24th of a wavelength can cause a signal reflection. 


The change in wire diameter due to the solder may change the impedance of that part of the line a little bit, but the overall length of that mismatched section (the solder blob) is completely insignificant at HF.