Yes, and those tolerances can sometimes matter also. The higher the power and higher the frequency, the more it can matter, depending on what part of the circuit we're talking. They do matter much less though, and good designs will have reasonable tolerance acceptance factored into their designs. Those tolerances aren't going to cause a massive difference in idle current through the FETs or cause them to be biased way off of where their load line should be set either, which was the point I was getting at.
And yes, you do bias FETs for a quiescent drain current, why wouldn't you? If you're just setting gate voltages, then you have no idea of where on the load line the devices are being biased due to variations in VGS(th). It could be almost anywhere. You could have 1 FET being driven into compression while another is barely turning on. That's an extreme example, but you get the point.
Bipolars have leakage current through the C-E junction just like FETs leak through the D-S junctions, that has zero at all to do with how you bias them. Depletion and enhancement mode just describes how the D-S channel operates. Depletion FETs require a negative gate voltage to cut-off channel current, enhancement mode FETs cut-off at 0 or positive voltage.
Having said that, every FET datasheet I've ever read, from J310 depletion JFETs and dual-gate Mosfets, clear up to >1KW LDMOS enhancement Mosfet devices, they all specify biasing conditions as IDQ, quiescent drain current. You need to know the no-signal drain current to be able to do the load line calculations for the designing stage. Once the circuit is designed, you can set the biasing by measuring the drain current and you'll be spot on, every time, regardless of any variation in VGS(th).
I'm self-taught, so I just go by the books that I've read. They all say to bias RF Power Mosfets by the drain current, and I've never had any issues as of yet. I don't see why it would be any different when using switching FETs in RF applications. The same rules apply. I'm always up for learning something new though.