There is a bit more to it than just snatching up a dave-made or whatever, hooking it up and yapping on it, that's for sure.
It's best, when choosing an amp, to use class AB only for HF, including CB. You can read or ask around for info on CB amps known to be class AB. I also recommend using a filtered amp (some Palomars are filtered, not sure about other 11m-only amps). If your amp is not filtered, use an external low-pass filter such as this:
RF LIMITED LOW PASS TVI FILTER DF-3000 3KW PEP new | eBay
This filter handles up to 3kW, but there are smaller, cheaper ones out there that handle less power.
To help reduce IMD it's best to find out what kind of transistors an amp uses and look up their datasheet online. You can then use the published power output figure for the transistor as a a guide as to what kind of clean power to expect from the amp.
As an example, let's take an amp that uses SD1446 transistors. Here's the datasheet for the SD1446:
http://www.datasheetcatalog.org/datasheet/stmicroelectronics/2805.pdf
You can see that the SD1446 is rated to 70W max. Using this number, you can estimate that 2 SD1446 transistors will give 140W as an absolute maximum without shortening the transistor's expected lifetime. It's good engineering practice (and good operating practice) to only drive the transistors to around 80% of their absolute maximum rating. That means that 2 SD1446s will give about 120W of clean power. At this level we still need the low-pass filter for harmonics, which are always present, but the IMD is reduced.
When you are hearing someone on SSB squawking on AM, you're hearing it because you are on almost the exact same frequency as the SSB signal. This is normal, and not a result of splatter. Two people on the same channel will interfere with each other on some level regardless of mode of operation. When you're on one channel and you can hear someone on an adjacent channel, usually it sounds like garbage not speech, that is splatter, and is the result of huge amounts of IMD being generated by an overdriven amplifier. When I was on Cb a lot I remember hearing guys 2 and 3 channels away from the one they were using. Drove me nuts...
Finally, the 50V device in this thread will be used in a base amplifier in my application, although I'm sure a boost converter could be built to supply 50V from an alternator. It would have to be pretty serious to power a big amplifier though.