Dean Street,
im afraid all you're going to find here is advice you don't want to hear.
Things such as, a 2 driving 4 pill linear amplifier is a stupid idea in the first place and would either blast the 4 pills right into saturation or be swamped so much that it negates the need for the 2 pill driver section.
or things like, bypassing the amp in a connex 4300-300 in order to run a 4 pill is not going to net you much more on the receiving radio, and will almost definitely be less than a 1 S unit gain.
or maybe, switching out 2290's for 2879's is not a simple process, and requires knowledge, skills, and test equipment in order to make it work.
please correct me if im wrong, but i get the impression that you are looking to make your watt meter move as far to the right as possible, all notions of good sense be damned.
If i am correct, you can be re-educated on this forum, but only if you want to see the truth.
many come here for similar advice and leave in a week claiming we are just a bunch of jerks who think they know it all, and don't know how things work in the CB world.
LC