Sure, lots of people run these together out of the box. Side band would have no issue at all. A 4w dead key on AM might make the amp run hotter than needed, but people do it any way.
Like Shadetree said they are used with 4w DK. He was one of the people here that helped me.
I am running one on my puny Cobra 18 which out of the box has a 2w DK. Only issue I had with mine is I needed to install their low pass filter in order to get the SWR’s to a reasonable level. It puts out more than the frequency that a CB antenna could take returning that back to the radio. The peeps here helped me out on that!! Good bang for your buck on that amp!