My experience seems to support this theory. After I sent it off, I checked for SW updates for my RT Systems SW, and sure enough, there was an update to the FTM-350 SW.The current theory is that using a memory/settings files from a pre-1.2 radio on a 1.2 radio is causing these lockups (when using RT Systems software).
I'm going to start with new files, export/import my channel data, and upload from the fresh file.