My wife and I also use VX-5Rs, and have been very happy with them. In hindsight however, I would have bought a radio with 2m/220/440, rather than 6m/2m/440.
6 meters is not very useful in a handheld. On the other hand, here in SoCal there are a number of 220 repeaters. I am in a club that has several 220 repeaters and a 440 repeater that is conveniently located.
If you actually plan to use other bands, a dual- or multi-band HT is worthwhile. If you are in area where most repeaters are on 2 meters, or most 440 repeaters are closed, you may be as well off with a 2 meter only rig.
2 meters is by far the most popular HT band, and most of the country has plenty of repeater coverage. A single band HT is also definately cheaper, with many good models in the $100 to $120 range. Stay away from the really cheap models, and any with less than 5 watts output. Almost all HTs allow you to reduce power to conserve batteries, but there are times when a few watts are needed. From my house I can hit several repeaters on a watt or less, but when you start getting more rural you need a bit more power.
Of course a good antenna will make more difference in practical range on VHF/UHF than increases in power. A rubber-ducky is about the least efficient antenna anyone uses--they are just much more convenient to carry.
The Buddypole is an HF antenna. There are a number of HT antennas that really boost performance over a stock rubber-ducky.
Look at Maldol, Larsen, and Diamond.
For portable use--like hiking and such, a "roll-up J-Pole" is a great idea. It is a full half-wave antenna that will have much better performance than a rubber-ducky. You can make your own (just do a google and you should find several sites with details) or buy one ready-made for about $20.
I have, or have had, HTs by Icom, Yaesu, and Alinco. I have had good performance from all of these. I have heard good things about kenwood.
Hope this helps--it is easy to ramble on for a while....
Dave_W6DPS