Sound wise, not really. I will challenge anyone to a blindfold test because CB or Ham is not HI-FI audio where the sheen from tube amps is only marginally noticeable.
I you'll always have the experts that can hear the difference. If a quality tube or transistor amplifier is ran within its limits minus a little to have headroom for overshoot no one can hear the difference. I've stumped a few local experts with the Pepsi challenge.
The difference is how the distortion sounds when the amplifier is overdriven. People won't run equipment with dynamic headroom in mind because it cost too much to have the watts they want. They can drive the piss out of an old sweep tube amp and it doesn't sound as shitty as an over driven 2 pill. That must mean the tubes just sound better.