Here's the diagram I have for the 250. Kinda short on detail.
C10 and C11 are the HV filter capacitors. If they are original, they should have failed years ago.
When they do fail, they tend to short. This will overload the rectifier diodes D1-D4. Odds are that they are damaged from that overload and are now shorted. If you'll find the transformer wire connected to the center lug of the High/Low switch, take it loose and insulate the end with tape. Now try to power it up.
If the fuse blows, the power transformer has failed. The fuse in this amplifier is sufficient to protect your house from a fire, but too large to protect the components in the amplifier from damage.
And if the fuse holds, the fan spins up and the tube filaments light up, you need to replace the HV rectifier diodes and the filter caps. We always replace the two bleeder resistors at the same time. Old ones can change resistance value and cause trouble.
Tubes are always a question. If you have access to a tube tester, making sure that none of the tubes have broken down and shorted inside will improve your odds of getting it back on the air.
You will probably need to use a series-connected pair of 1kV-rated rectifier diodes for each of the four single diodes you see in the diagram. Each of the four diodes would have to have a rating of 1500 Volts for this amplifier. Those are had to find, but the 1000-Volt 1N5408 recitifer is easy to find, especially on Fleabay.
Best of luck and 73