Whoa! 3 posts, and I have just finished on answering just one!
Hmm...Lays potato(e) chips...?
Is his computer a laptop? And does it's audio media (music and Mic) use single port input and output?
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Where would you start to find what's happened to these radios Handy Andy? I have no scope now the look for noise so I'm a bit under prepared at the moment but have most other test equipment, think I even have a sinad meter here somewhere.
The radio wouldn't put it out on the air, just internally like a birdie, only self induced squeal. So, it would be harder to see as far as RF goes, but audio wise, you'd know it - try a talkback method like the resistor from ext. SP to PA SP and see what talkback will reveal - because RF is setup with a pass band would be trimmed off, but the damage is being done inside the radio before if's finally trimmed off at the RF TX stage.
This setup in PA mode, would also make the Audio amp in the radio run hot too. So this may be the route to go, find some external speaker and a 16 ohm resistor - put it (resistor) in line IN SERIES with the EXT speaker - so you don't get blasted by the ultra high squeal you may not hear...
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Also the wattage starts out where it does when keyed without the audio line plugged in, but plugged in it will climb slowly in wattage when audio is applied.
Ok, there's the clue I'm cueing you in on. Nothing happens unless that port is connected. So if you're sure you're isolated from the Computer - how are you grounding the output from the computer to shield your radio?
As said in an earlier post - a line isolation transformer can work, but the losses are pretty heavy in the conversion process. You may need to somehow run a wire from your radios case, to the USB "metal shield" used for one of the USB ports as a means to find chassis ground to the PC, unless you know of another way to bond your radio to the PC's ground.
I'm glad to know you didn't just try another radio and wound up taking out two radios in this process, I think the main problem is finding the chassis ground reference for the PC side of things. Its' not always Chassis and 3rd wire plug grounding at the wall either - your issue may be a "floating ground" reference where the PC keeps pumping the voltage to keep the power flowing into the media port - it won't damage it until a breakdown voltage gets exceeded - that can take a while to achieve that. But,, meanwhile, the radio is suffering from the oscillation.